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KMID : 0380620100420040488
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Korean Journal of Food Science and Technology
2010 Volume.42 No. 4 p.488 ~ p.493
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Effects of Perilla frutescens Extract on Anti-allergic Reactions in a Mouse Model
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Ko Jung-A
Kim Gun-Hee
Park Ji-Yong
Han Chan-Kyu
Lim Hun-Sun
Park Hyun-Jin
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Abstract
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We investigated the effect of Perilla frutescens (PF) ethanol extract powder (PF-E30) on the local allergic reaction activated by anti-DNP IgE and the mast cell-mediated immediate-type allergic reactions induced by compound 48/80 in a mouse model. One gram of PF powder extracted with 30% ethanol at 80oC contained 12.3 mg of rosmarinic acid.
Oral administration of PF-E30 (0.1 to 0.5 mg/kg body weight) significantly reduced plasma histamine levels and inhibited histamine release from peritoneal mast cells in mice activated by compound 48/80 or anti-DNP IgE. Moreover PF-E30 dose-dependently inhibited the production of antigen-induced IgE. These results indicate that the PF ethanol extract inhibits mast cell-mediated immediate-type allergic reactions in vivo and in vitro.
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KEYWORD
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Perilla frutescens, rosmarinic acid, anti-allergic reaction, histamine, antigen-induced
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